Instituto Universitario de Biología Molecular

PUBLICACIONES CIENTÍFICAS 2021

1. Alcover-Sanchez, B., Garcia-Martin, G., Escudero-Ramirez, J., Gonzalez-Riano, C., Lorenzo, P., Gimenez-Cassina, A., Formentini, L., de la Villa-Polo, P., Pereira, M.P., Wandosell, F., Cubelos, B. Absence of R-Ras1 and R-Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model (2021) GLIA, 69 (3), pp. 619-637. Article

2. Alfaro-Ruiz, R., Martín-Belmonte, A., Aguado, C., Hernández, F., Moreno-Martínez, A.E., Ávila, J., Luján, R. The expression and localisation of g-protein-coupled inwardly rectifying potassium (GIRK) channels is differentially altered in the hippocampus of two mouse models of alzheimer’s disease (2021) International Journal of Molecular Sciences, 22 (20), art. no. 11106, Article

3. Allman, C.J., Gómez-Ortiz, D., Burke, A., Amils, R., Rodriguez, N., Fernández-Remolar, D. Hydrogeochemical variability of the acidic springs in the rio tinto headwaters (2021) Water (Switzerland), 13 (20), art. no. 2861, Article

4. Alonso-Barroso, E., Pérez, B., Desviat, L.R., Richard, E. Cardiomyocytes derived from induced pluripotent stem cells as a disease model for propionic academia (2021) International Journal of Molecular Sciences, 22 (3), art. no. 1161, pp. 1-14. Article

5. Alvarez-Franco, A., Rouco, R., Ramirez, R.J., Guerrero-Serna, G., Tiana, M., Cogliati, S., Kaur, K., Saeed, M., Magni, R., Enriquez, J.A., Sanchez-Cabo, F., Jalife, J., Manzanares, M. Transcriptome and proteome mapping in the sheep atria reveal molecular featurets of atrial fibrillation progression (2021) Cardiovascular Research, 117 (7), pp. 1760-1775. Article

6. Andreu, S., Ripa, I., Praena, B., López‐guerrero, J.A., Bello‐morales, R. The valproic acid derivative valpromide inhibits pseudorabies virus infection in swine epithelial and mouse neuroblastoma cell lines (2021) Viruses, 13 (12), art. no. 2522, . Article

7. Andreu, S., Ripa, I., Bello-Morales, R., López-Guerrero, J.A. Nebulized clodos technology shows clear virucidal properties against the human coronavirus hcov-229e at non-cytotoxic doses (2021) Viruses, 13 (3), art. no. 531, . Article

8. Arcones, A.C., Vila-Bedmar, R., Mirasierra, M., Cruces-Sande, M., Vallejo, M., Jones, B., Tomas, A., Mayor, F., Jr, Murga, C. GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo (2021) BMC Biology, 19 (1), art. no. 40, .Article

9. Arcones, A.C., Martínez‐cignoni, M.R., Vila‐bedmar, R., Yáñez, C., Lladó, I., Proenza, A.M., Mayor, F., Jr., Murga, C. Cardiac grk2 protein levels show sexual dimorphism during aging and are regulated by ovarian hormones (2021) Cells, 10 (3), art. no. 673, pp. 1-14. Article

10. Arcones, A.C., Murga, C., Penela, P., Inserte, J., Mayor, F., Jr. G protein–coupled receptor kinase 2 at crossroads of metabolic and cardiovascular diseases (2021) Current Opinion in Endocrine and Metabolic Research, 16, pp. 75-85. Review
11. Arribas-Blázquez, M., Piniella, D., Olivos-Oré, L.A., Bartolomé-Martín, D., Leite, C., Giménez, C., Artalejo, A.R., Zafra, F. Regulation of the voltage-dependent sodium channel NaV1.1 by AKT1 (2021) Neuropharmacology, 197, art. no. 108745, .Article

12. Bello-Morales, R., Andreu, S., Ripa, I., López-Guerrero, J.A. Hsv-1 and endogenous retroviruses as risk factors in demyelination (2021) International Journal of Molecular Sciences, 22 (11), art. no. 5738, Review

13. Benítez, M.J., Cuadros, R., Jiménez, J.S. Phosphorylation and dephosphorylation of tau protein by the catalytic subunit of PKA, as probed by electrophoretic mobility retard (2021) Journal of Alzheimer’s Disease, 79 (3), pp. 1143-1156. Article

14. Benito-Muñoz, C., Perona, A., Felipe, R., Pérez-Siles, G., Núñez, E., Aragón, C., López-Corcuera, B. Structural Determinants of the Neuronal Glycine Transporter 2 for the Selective Inhibitors ALX1393 and ORG25543 (2021) ACS Chemical Neuroscience, 12 (11), pp. 1860-1872. Article

15. Bosch, Sandra; Sanchez-Freire, Esther; Luisa del Pozo, Maria; Cesnik, Morana; Quesada, Jaime; Mate, Diana M.; Hernandez, Karel; Qi, Yuyin; Clapes, Pere; Vasic-Racki, Durda; Findrik Blazevic, Zvjezdana; Berenguer, Jose; Hidalgo, Aurelio Thermostability Engineering of a Class II Pyruvate Aldolase from Escherichia coli by in Vivo Folding Interference (2021) Acs Sustainable Chemistry & Engineering, 9 Article

16. Cabezudo, S., Sanz-Flores, M., Caballero, A., Tasset, I., Rebollo, E., Diaz, A., Aragay, A.M., Cuervo, A.M., Mayor, F., Jr., Ribas, C. Gαq activation modulates autophagy by promoting mTORC1 signaling (2021) Nature Communications, 12 (1), art. no. 4540, .Article

17. Calle, A., Gutiérrez-Reinoso, M.Á., Re, M., Blanco, J., De la Fuente, J., Monguió-Tortajada, M., Borràs, F.E., Yáñez-Mó, M., Ramírez, M.Á. Bovine peripheral blood MSCs chemotax towards inflammation and embryo implantation stimuli (2021) Journal of Cellular Physiology, 236 (2), pp. 1054-1067. Article

18. Calle, Alexandra; Toribio, Victor; Yanez-Mo, Maria; Ramirez, Miguel Angel Embryonic trophectoderm secretomics reveals chemotactic migration and intercellular communication of endometrial and circulating mscs in embryonic implantation International Journal of Molecular Sciences, 22 pp5638 Article

19. Callejas-Hernández, F., Herreros-Cabello, A., del Moral-Salmoral, J., Fresno, M., Gironès, N. The Complete Mitochondrial DNA of Trypanosoma cruzi: Maxicircles and Minicircles (2021) Frontiers in Cellular and Infection Microbiology, 11, art. no. 672448, . Article

20. Camacho, E., Fuente, S.G.L., Solana, J.C., Rastrojo, A., Carrasco-Ramiro, F., Requena, J.M., Aguado, B. Gene annotation and transcriptome delineation on a de novo genome assembly for the reference leishmania major friedlin strain (2021) Genes, 12 (9), art. no. 1359, .Article

21. Campos-Silva, C., Cáceres-Martell, Y., López-Cobo, S., Rodriguez, M.J., Jara, R., Yáñez-Mó, M., Valés-Gómez, M. An Immunocapture-Based Assay for Detecting Multiple Antigens in Melanoma-Derived Extracellular Vesicles (2021) Methods in Molecular Biology, 2265, pp. 323-344. Book Chapter

22. Cardenes, Beatriz; Clares, Irene; Toribio, Victor; Pascual, Lucia; Lopez-Martin, Soraya; Torres-Gomez, Alvaro; Sainz de la Cuesta, Ricardo; Lafuente, Esther M.; Lopez-Cabrera, Manuel; Yanez-Mo, Maria; Cabanas, Carlos Cellular integrin α5β1 and exosomal adam17 mediate the binding and uptake of exosomes produced by colorectal carcinoma cells (2021) International Journal of Molecular Sciences, 22 pp. 9938 Article

23. Carrasco, E., Gómez de las Heras, M.M., Gabandé-Rodríguez, E., Desdín-Micó, G., Aranda, J.F., Mittelbrunn, M. The role of T cells in age-related diseases (2021) Nature Reviews Immunology, Review

24. Casares-Arias, Javier; Miguez, David G.; Bernabé-Rubio, Miguel; Correas, Isabel; Casares-Arias, Javier; Rangel, Laura; Fernández-Barrera, Jaime; Labat-de-Hoz, Leticia; Rubio-Ramos, Armando; Alonso, Miguel A Midbody Remnant Inheritance Is Regulated by the ESCRT Subunit CHMP4C (2021) Iscience, 23 Article

25. Castillo-González, R., Cibrian, D., Fernández-Gallego, N., Ramírez-Huesca, M., Saiz, M.L., Navarro, M.N., Fresno, M., de la Fuente, H., Sánchez-Madrid, F. Galectin-1 Expression in CD8+ T Lymphocytes Controls Inflammation in Contact Hypersensitivity (2021) Journal of Investigative Dermatology, 141 (6), pp. 1522-1532.e3. Article

26. Cestero, Juan J.; Castanheira, Sonia; Pucciarelli, M. Graciela; Garcia-del Portillo, Francisco A Novel Salmonella Periplasmic Protein Controlling Cell Wall Homeostasis and Virulence 82021) Frontiers In Microbiology, 12 Art.633701 Article

27. Civera-Tregón, A., Domínguez, L., Martínez-Valero, P., Serrano, C., Vallmitjana, A., Benítez, R., Hoenicka, J., Satrústegui, J., Palau, F. Mitochondria and calcium defects correlate with axonal dysfunction in GDAP1-related Charcot-Marie-Tooth mouse model (2021) Neurobiology of Disease, 152, art. no. 105300, . Article

28. Cobaleda, C., Vicente-Dueñas, C., Sanchez-Garcia, I. Infectious triggers and novel therapeutic opportunities in childhood B cell leukaemia (2021) Nature Reviews Immunology, 21 (9), pp. 570-581.Review

29. Cobaleda, C., Sánchez-García, I. Leukemia stem cell drug discovery (2021) Methods in Molecular Biology, 2185, pp. 39-48. Book Chapter

30. Cogliati, S., Cabrera-Alarcón, J.L., Enriquez, J.A. Regulation and functional role of the electron transport chain supercomplexes (2021) Biochemical Society Transactions, 49 (6), pp. 2655-2668. Review

31. Cogliati, S., Herranz, F., Ruiz-Cabello, J., Enríquez, J.A. Digitonin concentration is determinant for mitochondrial supercomplexes analysis by BlueNative page (2021) Biochimica et Biophysica Acta – Bioenergetics, 1862 (1), art. no. 148332, Article

32. Danbolt, N.C., López-Corcuera, B., Zhou, Y. Reconstitution of GABA, Glycine and Glutamate Transporters (2021) Neurochemical Research, .Article

33. De la Rocha-Muñoz, A., Núñez, E., Vishwanath, A.A., Gómez-López, S., Dhanasobhon, D., Rebola, N., López-Corcuera, B., de Juan-Sanz, J., Aragón, C. The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo (2021) Communications Biology, 4 (1), art. no. 1197, Article

34. De la Rocha-Muñoz, A., Melgarejo, E., Aragón, C., López-Corcuera, B. Rescue of two trafficking-defective variants of the neuronal glycine transporter GlyT2 associated to hyperekplexia (2021) Neuropharmacology, 189, art. no. 108543.Article

35. Del Rey, M.J., Meroñõ, C., Municio, C., Usategui, A., Mittelbrunn, M., Garcıá-Consuegra, I., Criado, G., Pablos, J.L. TFAM-deficient mouse skin fibroblasts – an ex vivo model of mitochondrial dysfunction (2021) DMM Disease Models and Mechanisms, 14 (8), art. no. dmm048995, Article

36. Dessaux, Charlotte; Pucciarelli, M Graciela; Guerreiro, Duarte N.; O’Byrne, Conor P.; García-Del Portillo, Francisco Activation of the Listeria monocytogenes Stressosome in the Intracellular Eukaryotic Environment (2021) Applied and Environmental Microbiology, 87 Article

37. Echarren, M.L., Figueroa, N.R., Vitor-Horen, L., Pucciarelli, M.G., García-del Portillo, F., Soncini, F.C. Balance between bacterial extracellular matrix production and intramacrophage proliferation by a Salmonella-specific SPI-2-encoded transcription factor (2021) Molecular Microbiology, 116 (4), pp. 1022-1032. Article

38. Esparza-Moltó, P.B., Romero-Carramiñana, I., de Arenas, C.N., Pereira, M.P., Blanco, N., Pardo, B., Bates, G.R., Sánchez-Castillo, C., Artuch, R., Murphy, M.P., Esteban, J.A., Cuezva, J.M. Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition (2021) PLoS Biology, 19 (5), art. no. e3001252, .Article

39. Fernández, L., Solana, J.C., Sánchez, C., Jiménez, M.Á., Requena, J.M., Coler, R., Reed, S.G., Valenzuela, J.G., Kamhawi, S., Oliveira, F., Fichera, E., Glueck, R., Bottazzi, M.E., Gupta, G., Cecilio, P., Pérez-Cabezas, B., Cordeiro-Da-silva, A., Gradoni, L., Carrillo, E., Moreno, J. Protective efficacy in a hamster model of a multivalent vaccine for human visceral leishmaniasis (Mulevaclin) consisting of the kmp11, leish-f3+, and ljl143 antigens in virosomes, plus gla-se adjuvant (2021) Microorganisms, 9 (11), art. no. 2253, . Article

40. Fernández-Remolar, D.C., Carrizo, D., Harir, M., Huang, T., Amils, R., Schmitt-Kopplin, P., Sánchez-García, L., Gomez-Ortiz, D., Malmberg, P. Unveiling microbial preservation under hyperacidic and oxidizing conditions in the Oligocene Rio Tinto deposit (2021) Scientific Reports, 11 (1), art. no. 21543, .Article

41. Fernández-Remolar, D.C., Gomez-Ortiz, D., Huang, T., Anglés, A., Shen, Y., Hu, Q., Amils, R., Rodríguez, N., Escudero, C., Banerjee, N.R. The Molecular Record of Metabolic Activity in the Subsurface of the Río Tinto Mars Analog (2021) Astrobiology, 21 (11), pp. 1387-1405. Article

42. Fernández-Remolar, D.C., Gómez-Ortiz, D., Malmberg, P., Huang, T., Shen, Y., Anglés, A., Amils, R. Preservation of underground microbial diversity in ancient subsurface deposits (>6 ma) of the rio tinto basement (2021) Microorganisms, 9 (8), art. no. 1592, .Article

43. Francisco, S., Arranz, A., Merino, J., Punzón, C., Perona, R., Fresno, M. Early p38 Activation Regulated by MKP-1 Is Determinant for High Levels of IL-10 Expression Through TLR2 Activation (2021) Frontiers in Immunology, 12, art. no. 660065, .Article

44. Fresno, M., Gironès, N. Myeloid-Derived Suppressor Cells in Trypanosoma cruzi Infection (2021) Frontiers in Cellular and Infection Microbiology, 11, art. no. 737364, .Review

45. Galán-Martínez, J., Stamatakis, K., Sánchez-Gómez, I., Vázquez-Cuesta, S., Gironés, N., Fresno, M. Isoform-specific effects of transcription factor TCFL5 on the pluripotency-related genes SOX2 and KLF4 in colorectal cancer development (2021) Molecular Oncology, . Article

46. García-Catalán, S., González-Moreno, L., del Arco, A. Ca2+-regulated mitochondrial carriers of ATP-Mg2+/Pi: Evolutionary insights in protozoans (2021) Biochimica et Biophysica Acta – Molecular Cell Research, 1868 (7), art. no. 119038, Article

47. García-Escudero, V., Ruiz-Gabarre, D., Gargini, R., Pérez, M., García, E., Cuadros, R., Hernández, I.H., Cabrera, J.R., García-Escudero, R., Lucas, J.J., Hernández, F., Ávila, J. A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer’s disease (2021) Acta Neuropathologica, 142 (1), pp. 159-177. Article

48. García-Magro, N., Martin, Y.B., Negredo, P., Zafra, F., Avendaño, C. Microglia and inhibitory circuitry in the medullary dorsal horn: Laminar and time-dependent changes in a trigeminal model of neuropathic pain (2021) International Journal of Molecular Sciences, 22 (9), art. no. 4564, .Article

49. Garcia-Navas, Rosula; Liceras-Boillos, Pilar; Gomez, Carmela; Baltanas, Fernando C.; Calzada, Nuria; Nuevo-Tapioles, Cristina; Cuezva, Jose M.; Santos, Eugenio. Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis (2021) Oncogene, 732120 article; early access

50. García-Rodríguez, D., Giménez-Cassina, A. Ketone Bodies in the Brain Beyond Fuel Metabolism: From Excitability to Gene Expression and Cell Signaling (2021) Frontiers in Molecular Neuroscience, 14, art. no. 732120, .Article

51. Geiger, S.S., Traba, J., Richoz, N., Farley, T.K., Brooks, S.R., Petermann, F., Wang, L., Gonzalez, F.J., Sack, M.N., Siegel, R.M. Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signaling (2021) Nature Communications, 12 (1), art. no. 2745, .Article

52. Gil-Ranedo, J., Gallego-García, C., Almendral, J.M.Viral targeting of glioblastoma stem cells with patient-specific genetic and post-translational p53 deregulations (2021) Cell Reports, 36 (10), art. no. 109673, Article

53. Gómez, I., López, M.C., Rastrojo, A., Lorenzo-Díaz, F., Requena, J.M., Aguado, B., Valladares, B., Thomas, M.C. Variability of the Pr77 sequence of L1Tc retrotransposon among six T. cruzi strains belonging to different discrete typing units (DTUs) (2021) Acta Tropica, 222, art. no. 106053, .Article

54. González-Alfonso, J.L., Poveda, A., Arribas, M., Hirose, Y., Fernández-Lobato, M., Olmo Ballesteros, A., Jiménez-Barbero, J., Plou, F.J.Polyglucosylation of Rutin Catalyzed by Cyclodextrin Glucanotransferase from Geobacillus sp.: Optimization and Chemical Characterization of Products (2021) Industrial and Engineering Chemistry Research, .

55. Hammond, S.M., Aartsma-Rus, A., Alves, S., Borgos, S.E., Buijsen, R.A.M., Collin, R.W.J., Covello, G., Denti, M.A., Desviat, L.R., Echevarría, L., Foged, C., Gaina, G., Garanto, A., Goyenvalle, A.T., Guzowska, M., Holodnuka, I., Jones, D.R., Krause, S., Lehto, T., Montolio, M., Van Roon-Mom, W., Arechavala-Gomeza, V. Delivery of oligonucleotide-based therapeutics: challenges and opportunities (2021) EMBO Molecular Medicine, 13 (4), art. no. e13243, . Review

56. Hernandez, Ivo H.; Villa-Gonzalez, Mario; Martin, Gerardo; Soto, Manuel; Perez-Alvarez, Maria Jose Glial Cells as Therapeutic Approaches in Brain Ischemia-Reperfusion Injury (2021) Cells, 10-eaaz9705 Review

57. Horndler, L., Delgado, P., Abia, D., Balabanov, I., Martínez-Fleta, P., Cornish, G., Llamas, M.A., Serrano-Villar, S., Sánchez-Madrid, F., Fresno, M., van Santen, H.M., Alarcón, B. Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS-CoV-2 spike protein (2021) EMBO Molecular Medicine, 13 (3), art. no. e13549, . Article

58. Huesa, J., Giner-Lamia, J., Pucciarelli, M.G., Paredes-Martínez, F., Portillo, F.G.-D., Marina, A., Casino, P. Structure-based analyses of Salmonella RcsB variants unravel new features of the Rcs regulon (2021) Nucleic Acids Research, 49 (4), pp. 2357-2374. Article

59. Jiménez, E., Fornés, A., Felipe, R., Núñez, E., Aragón, C., López-Corcuera, B. Calcium-Dependent Regulation of the Neuronal Glycine Transporter GlyT2 by M2 Muscarinic Acetylcholine Receptors (2021) Neurochemical Research, .Article

60. Jiménez, E., Piniella, D., Giménez, C., Zafra, F. Regulation of the Glycine Transporter GLYT1 by microRNAs (2021) Neurochemical Research, .Article

61. Jiménez-Ortega, Elena; Kidibule, Peter Elias; Fernández-Lobato, María; Sanz-Aparicio, Julia. Structural inspection and protein motions modelling of a fungal glycoside hydrolase family 18 chitinase by crystallography depicts a dynamic enzymatic mechanism (2021) Computational and Structural Biotechnology Journal, 19 Article

62. Jiménez-Saucedo, T., Berlanga, J.J., Rodríguez-Gabriel, M. Translational control of gene expression by eIF2 modulates proteostasis and extends lifespan (2021) Aging, 13 (8), pp. 10989-11009. Article

63. Kidibule, Peter E.; Costa, Jessica; Atrei, Andrea; Plou, Francisco J.; Fernandez-Lobato, Maria; Pogni, Rebecca. Production and characterization of chitooligosaccharides by the fungal chitinase Chit42 immobilized on magnetic nanoparticles and chitosan beads: selectivity, specificity and improved operational utility (2021) Rsc Advances, 11 Article

64. Kristen, H., Sastre, I., Aljama, S., Fuentes, M., Recuero, M., Frank-García, A., Martin, A., Sanchez-Juan, P., Lage, C., Bullido, M.J., Aldudo, J. LAMP2 deficiency attenuates the neurodegeneration markers induced by HSV-1 infection(2021) Neurochemistry International, 146, art. no. 105032, .Article

65. Kumble, Smitha; Levy, Amanda M.; Punetha, Jaya; Gao, Hua; Ah Mew, Nicholas; Anyane-Yeboa, Kwame; Benke, Paul J.; Berger, Sara M.; Bjerglund, Lise; Campos-Xavier, Belinda; Ciliberto, Michael; Cohen, Julie S.; Comi, Anne M.; Curry, Cynthia; Damaj, Lena; Denommé-Pichon, Anne-Sophie; Emrick, Lisa; Faivre, Laurence; Fasano, Mary Beth; Fiévet, Alice; Finkel, Richard S.; García-Miñaúr, Sixto; Gerard, Amanda; Gomez-Puertas, Paulino; Guillen Sacoto, Maria J.; Hoffman, Trevor L.; Howard, Lillian; Iglesias, Alejandro D.; Izumi, Kosuke; Larson, Austin; Leiber, Anja; Lozano, Reymundo; Marcos-Alcalde, Iñigo; Mintz, Cassie S.; Mullegama, Sureni V.; Møller, Rikke S.; Odent, Sylvie; Oppermann, Henry; Ostergaard, Elsebet; Pacio-Míguez, Marta; Palomares-Bralo, Maria; Parikh, Sumit; Paulson, Anna M.; Platzer, Konrad; Posey, Jennifer E.; Potocki, Lorraine; Revah-Politi, Anya; Rio, Marlene; Ritter, Alyssa L.; Robinson, Scott; Rosenfeld, Jill A.; Santos-Simarro, Fernando; Sousa, Sérgio B.; Wéber, Mathys; Xie, Yili; Chung, Wendy K.; Brown, Natasha J.; Tümer, Zeynep; Acosta, Maria T.; Adam, Margaret; Adams, David R.; Agrawal, Pankaj B.; Alejandro, Mercedes E.; Alvey, Justin; Amendola, Laura; Andrews, Ashley; Ashley, Euan A.; Azamian, Mahshid S.; Bacino, Carlos A.; Bademci, Guney; Baker, Eva; Balasubramanyam, Ashok; Baldridge, Dustin; Bale, Jim; Bamshad, Michael; Barbouth, Deborah; Bayrak-Toydemir, Pinar; Beck, Anita; Beggs, Alan H.; Behrens, Edward; Bejerano, Gill; Bennet, Jimmy; Berg-Rood, Beverly; Bernstein, Jonathan A.; Berry, Gerard T.; Bican, Anna; Bivona, Stephanie; Blue, Elizabeth; Bohnsack, John; Bonnenmann, Carsten; Bonner, Devon; Botto, Lorenzo; Boyd, Brenna; Briere, Lauren C.; Brokamp, Elly; Brown, Gabrielle; Burke, Elizabeth A.; Burrage, Lindsay C.; Butte, Manish J.; Byers, Peter; Byrd, William E.; Carey, John; Carrasquillo, Olveen; Chang, Ta Chen Peter; Chanprasert, Sirisak; Chao, Hsiao-Tuan; Clark, Gary D.; Coakley, Terra R.; Cobban, Laurel A.; Cogan, Joy D.; Coggins, Matthew; Cole, F. Sessions; Colley, Heather A.; Cooper, Cynthia M.; Cope, Heidi; Craigen, William J.; Crouse, Andrew B.; Cunningham, Michael; D’Souza, Precilla; Dai, Hongzheng; Dasari, Surendra; Davis, Joie; Dayal, Jyoti G.; Deardorff, Matthew; Dell’Angelica, Esteban C.; Dhar, Shweta U.; Dipple, Katrina; Doherty, Daniel; Dorrani, Naghmeh; Doss, Argenia L.; Douine, Emilie D.; Draper, David D.; Duncan, Laura; Earl, Dawn; Eckstein, David J.; Eng, Christine M.; Esteves, Cecilia; Falk, Marni; Fernandez, Liliana; Ferreira, Carlos; Fieg, Elizabeth L.; Findley, Laurie C.; Fisher, Paul G.; Fogel, Brent L.; Forghani, Irman; Fresard, Laure; Gahl, William A.; Glass, Ian; Gochuico, Bernadette; Godfrey, Rena A.; Golden-Grant, Katie; Goldman, Alica M.; Goldrich, Madison P.; Goldstein, David B.; Grajewski, Alana; Groden, Catherine A.; Gutierrez, Irma; Hahn, Sihoun; Hamid, Rizwan; Hanchard, Neil A.; Hassey, Kelly; Hayes, Nichole; High, Frances; Hing, Anne; Hisama, Fuki M.; Holm, Ingrid A.; Hom, Jason; Horike-Pyne, Martha; Huang, Alden; Huang, Yong; Huryn, Laryssa; Isasi, Rosario; Jamal, Fariha; Jarvik, Gail P.; Jarvik, Jeffrey; Jayadev, Suman; Karaviti, Lefkothea; Kennedy, Jennifer; Kiley, Dana; Kobren, Shilpa N.; Kohane, Isaac S.; Kohler, Jennefer N.; Krakow, Deborah; Krasnewich, Donna M.; Kravets, Elijah; Korrick, Susan; Koziura, Mary; Krier, Joel B.; Lalani, Seema R.; Lam, Byron; Lam, Christina; LaMoure, Grace L.; Lanpher, Brendan C.; Lanza, Ian R.; Latham, Lea; LeBlanc, Kimberly; Lee, Brendan H. et al. The clinical and molecular spectrum of QRICH1 associated neurodevelopmental disorder (2021) Human Mutation. Article

66. Labat-de-Hoz, L., Rubio-Ramos, A., Casares-Arias, J., Bernabé-Rubio, M., Correas, I., Alonso, M.A. A Model for Primary Cilium Biogenesis by Polarized Epithelial Cells: Role of the Midbody Remnant and Associated Specialized Membranes (2021) Frontiers in Cell and Developmental Biology, 8, art. no. 622918, .Review

67. Lafarga, V., Sirozh, O., Díaz-López, I., Galarreta, A., Hisaoka, M., Zarzuela, E., Boskovic, J., Jovanovic, B., Fernandez-Leiro, R., Muñoz, J., Stoecklin, G., Ventoso, I., Fernandez-Capetillo, O. Widespread displacement of DNA- and RNA-binding factors underlies toxicity of arginine-rich cell-penetrating peptides (2021) EMBO Journal, 40 (13), art. no. e103311, Article

68. Lechuga, A.; Kazlauskas, D.; Salas, M.; Redrejo-Rodriguez, M. Unlimited Cooperativity of Betatectivirus SSB, a Novel DNA Binding Protein Related to an Atypical Group of SSBs From Protein-Primed Replicating Bacterial Viruses (2021) Frontiers In Microbiology, 12- 11105 Article

69. Lechuga, A., Lood, C., Berjón-Otero, M., Del Prado, A., Wagemans, J., van Noort, V., Lavigne, R., Salas, M., Redrejo-Rodríguez, M. Unraveling protein interactions between the temperate virus Bam35 and its bacillus host using an integrative yeast two hybrid–high throughput sequencing approach (2021) International Journal of Molecular Sciences, 22 (20), art. no. 11105, .Article

70. Llorente, P., Mejías, V., Sastre, I., Recuero, M., Aldudo, J., Bullido, M.J. Matrix metalloproteinase 14 regulates HSV-1 infection in neuroblastoma cells (2021) Antiviral Research, 192, art. no. 105116, .Article

71. López-Nieva, P., González-Sánchez, L., Cobos-Fernández, M.Á., Córdoba, R., Santos, J., Fernández-Piqueras, J. More Insights on the Use of γ-Secretase Inhibitors in Cancer Trea tment (2021) Oncologist, 26 (2), pp. e298-e305. Article

72. Martínez, J.M., Escudero, C., Rodríguez, N., Rubin, S., Amils, R. Subsurface and surface halophile communities of the chaotropic Salar de Uyuni (2021) Environmental Microbiology, 23 (7), pp. 3987-4001. Article

73. Martinez, J.M., Escudero, C., Leandro, T., Mateos, G., Amils, R. Draft genome sequence of pseudomonas sp strain t2.31d-1, isolated from a drilling core sample obtained 414 meters below surface in the iberian pyrite belt (2021) Microbiology Resource Announcements, 10 (1), art. no. e01165-20, . Article

74. Martín-González, N., Ibáñez-Freire, P., Ortega-Esteban, Á., Laguna-Castro, M., San Martín, C., Valbuena, A., Delgado-Buscalioni, R., De Pablo, P.J. Long-Range Cooperative Disassembly and Aging during Adenovirus Uncoating (2021) Physical Review X, 11 (2), art. no. 021025, .Article

75. Miguel-Ruano, Vega; Rivera, Ivanna; Rajkovic, Jelena; Knapik, Kamila; Torrado, Ana; Otero, Jose Manuel; Beneventi, Elisa; Becerra, Manuel; Sanchez-Costa, Mercedes; Hidalgo, Aurelio; Berenguer, Jose; Gonzalez-Siso, Maria-Isabel; Cruces, Jacobo; Rua, L. Maria; Hermoso, A. Juan Biochemical and Structural Characterization of a novel thermophilic esterase EstD11 provide catalytic insights for the HSL family (2021) Computational and Structural Biotechnology Journal, 19 pp. 3212 Article

76. Miguez, N., Kidibule, P., Santos-Moriano, P., Ballesteros, A.O., Fernandez-Lobato, M., Plou, F.J. Enzymatic synthesis and characterization of different families of chitooligosaccharides and their bioactive properties (2021) Applied Sciences (Switzerland), 11 (7), art. no. 3212, .Article

77. Mittelbrunn, M., Kroemer, G. Hallmarks of T cell aging (2021) Nature Immunology, 22 (6), pp. 687-698. Review

78. Moreno-Lorite, J., Pérez-Luz, S., Katsu-Jiménez, Y., Oberdoerfer, D., Díaz-Nido, J. DNA repair pathways are altered in neural cell models of frataxin deficiency (2021) Molecular and Cellular Neuroscience, 111, art. no. 103587, .Article

79. Navarro, M.N., Gómez de las Heras, M.M., Mittelbrunn, M. Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing (2021) British Journal of Pharmacology, . Review

80. Nocua, P.A., Requena, J.M., Puerta, C.J. Identification of the interactomes associated with SCD6 and RBP42 proteins in Leishmania braziliensis (2021) Journal of Proteomics, 233, art. no. 104066, .Article

81. Nuevo-Tapioles, C., Santacatterina, F., Sánchez-Garrido, B., De Arenas, C.N., Robledo-Bérgamo, A., Martínez-Valero, P., Cantarero, L., Pardo, B., Hoenicka, J., Murphy, M.P., Satrústegui, J., Palau, F., Cuezva, J.M. Effective therapeutic strategies in a preclinical mouse model of Charcot-Marie-Tooth disease (2021) Human Molecular Genetics, 30 (24), pp. 2441-2455. Article

82. Ocana-Santero, G., Díaz-Nido, J., Herranz-Martín, S. Future prospects of gene therapy for Friedreich’s ataxia (2021) International Journal of Molecular Sciences, 22 (4), art. no. 1815, pp. 1-18. Review

83. Papazoglu, G.M., Cubilla, M., Pereyra, M., de Kremer, R.D., Pérez, B., Sturiale, L., Asteggiano, C.G. Mass spectrometry glycophenotype characterization of ALG2-CDG in Argentinean patients with a new genetic variant in homozygosis (2021) Glycoconjugate Journal e21213 Article;early access

84. Piedrabuena, D., Rumbero, Á., Pires, E., Leal-Duaso, A., Civera, C., Fernández-Lobato, M., Hernaiz, M.J. Enzymatic synthesis of novel fructosylated compounds by Ffase fromSchwanniomyces occidentalisin green solvents (2021) RSC Advances, 11 (39), pp. 24312-24319. Article

85. Piniella, D., Martínez-Blanco, E., Bartolomé-Martín, D., Sanz-Martos, A.B., Zafra, F. Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter (2021) Cellular and Molecular Life Sciences, 78 (23), pp. 7733-7756. Article

86. Quereda, J.J., Morón-García, A., Palacios-Gorba, C., Dessaux, C., García-del Portillo, F., Pucciarelli, M.G., Ortega, A.D. Pathogenicity and virulence of Listeria monocytogenes: A trip from environmental to medical microbiology (2021) Virulence, 12 (1), pp. 2509-2545. Review

87. Raboso-Gallego, J., Casado-García, A., Jiang, X., Isidro-Hernández, M., Gentles, A.J., Zhao, S., Natkunam, Y., Blanco, O., Domínguez, V., Pintado, B., Alonso-López, D., De Las Rivas, J., Vicente-Dueñas, C., Lossos, I.S., Sanchez-Garcia, I. Conditional expression of HGAL leads to the development of diffuse large B-cell lymphoma in mice (2021) Blood, 137 (13), pp. 1741-1753. Article

88. Reglero, C., Del Castillo, B.O., Rivas, V., Mayor, F., Jr., Penela, P. MDM2-mediated downmodulation of GRK2 restricts centrosome separation for proper chromosome congression (2021) Cells, 10 (4), art. no. 729, .Article

89. Ripa, I., Andreu, S., López-Guerrero, J.A., Bello-Morales, R. Membrane Rafts: Portals for Viral Entry (2021) Frontiers in Microbiology, 12, art. no. 631274,.Review

90. Rodrigo-Frutos, D., Jiménez-Ortega, E., Piedrabuena, D., Ramírez-Escudero, M., Míguez, N., Plou, F.J., Sanz-Aparicio, J., Fernández-Lobato, M. New insights into the molecular mechanism behind mannitol and erythritol fructosylation by β-fructofuranosidase from Schwanniomyces occidentalis (2021) Scientific Reports, 11 (1), art. no. 7158, Article

91. Rodríguez-Angulo, H.O., Colombet-Naranjo, D., Maza, M.C., Poveda, C., Herreros-Cabello, A., Mendoza, I., Perera, J.C., Goyo, J.D., Gironès, N., Fresno, M. Molecular remodeling of cardiac sinus node associated with acute chagas disease miocarditis (2021) Microorganisms, 9 (11), art. no. 2208, .Article

92. Rodríguez-Angulo, H.O., Lamsfus-Calle, A., Isoler-Alcaráz, J., Galán-Martínez, J., Herreros-Cabello, A., Callejas-Hernández, F., Chorro-de-Villaceballos, M.A., Maza, M.C., Santi-Rocca, J., Poveda, C., Moral-Salmoral, J.D., Marques, J., Mendoza, I., Ramírez, J.D., Guhl, F., Carrillo, I., Pérez-Tanoira, R., Górgolas, M., Pérez-Ayala, A., Monge-Maillo, B., Norman, F., Pérez-Molina, J.A., López-Vélez, R., Fresno, M., Gironès, N. Autoantibodies against the immunodominant sCha epitope discriminate the risk of sudden death in chronic Chagas cardiomyopathy (2021) Annals of the New York Academy of Sciences, 1497 (1), pp. 27-38. Article

93. Rojano, Elena; Cordoba-Caballero, Jose; Jabato, Fernando M.; Gallego, Diana; Serrano, Mercedes; Perez, Belen; Pares-Aguilar, Alvaro; Perkins, James R.; Ranea, Juan A. G.; Seoane-Zonjic, Pedro Evaluating, filtering and clustering genetic disease cohorts based on human phenotype ontology data with cohort analyzer(2021) Journal of Personalized Medicine, 11 Article

94. Rothenbucher, Theresa S. P.; Gurbuz, Hakan; Pereira, Marta P.; Heiskanen, Arto; Emneus, Jenny; Martinez-Serrano, Alberto. Next generation human brain models: engineered flat brain organoids featuring gyrification (2021) Biofabrication, 13 Article

95. Royo, F., Azkargorta, M., Lavin, J.L., Clos-Garcia, M., Cortazar, A.R., Gonzalez-Lopez, M., Barcena, L., del Portillo, H.A., Yáñez-Mó, M., Marcilla, A., Borras, F.E., Peinado, H., Guerrero, I., Váles-Gómez, M., Cereijo, U., Sardon, T., Aransay, A.M., Elortza, F., Falcon-Perez, J.M. Extracellular Vesicles From Liver Progenitor Cells Downregulates Fibroblast Metabolic Activity and Increase the Expression of Immune-Response Related Molecules (2021) Frontiers in Cell and Developmental Biology, 8, art. no. 613583, Article

96. Rubio, C., Lizárraga, E., Álvarez-Cilleros, D., Pérez-Pardo, P., Sanmartín-Salinas, P., Val Toledo-Lobo, M., Alvarez, C., Escrivá, F., Fernández-Lobato, M., Guijarro, L.G., Valverde, A.M., Carrascosa, J.M. Aging in Male Wistar Rats Associates with Changes in Intestinal Microbiota, Gut Structure, and Cholecystokinin-Mediated Gut-Brain Axis Function (2021) Journals of Gerontology – Series A Biological Sciences and Medical Sciences, 76 (11), pp. 1915-1921. Article

97. Rubio-Ramos, A., Labat-De-hoz, L., Correas, I., Alonso, M.A. The mal protein, an integral component of specialized membranes, in normal cells and cancer (2021) Cells, 10 (5), art. no. 1065, .Article

98. Sacristán-Horcajada, E., González-de la Fuente, S., Peiró-Pastor, R., Carrasco-Ramiro, F., Amils, R., Requena, J.M., Berenguer, J., Aguado, B. ARAMIS: From systematic errors of NGS long reads to accurate assemblies (2021) Briefings in bioinformatics, 22 (6), .Article

99. Sánchez-García, I., Cobaleda, C .Leukemia stem cells: concept and implications (2021) Methods in Molecular Biology, 2185, pp. 25-37. Book Chapter

100. Sánchez-González, C., Formentini, L. An optimized protocol for coupling oxygen consumption rates with β-oxidation in isolated mitochondria from mouse soleus (2021) STAR Protocols, 2 (3), art. no. 100735, .Article

101. Sanz, J.L., Rodriguez, N., Escudero, C., Carrizo, D., Amils, R. Biological production of H2, CH4 and CO2 in the deep subsurface of the Iberian Pyrite Belt (2021) Environmental Microbiology, 23 (7), pp. 3913-3922. Article

102. Sanz, J.L., Rodríguez, N., Escudero, C., Carrizo, D., Amils, R., Gómez, F. Methanogenesis at high temperature, high ionic strength and low ph in the volcanic area of dallol, Ethiopia (2021) Microorganisms, 9 (6), art. no. 1231, . Article

103. Smit, M.J., Schlecht-Louf, G., Neves, M., Van Den Bor, J., Penela, P., Siderius, M., Bachelerie, F., Mayor, F. The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting (2021) Annual Review of Pharmacology and Toxicology, 61, pp. 541-563. Article

104. Solana, J.C., Moreno, J., Iborra, S., Soto, M., Requena, J.M. Live attenuated vaccines, a favorable strategy to provide long-term immunity against protozoan diseases (2021) Trends in Parasitology. Review

105. Soto, M., Ramírez, L., Solana, J.C., Cook, E.C.L., Hernández-García, E., Requena, J.M., Iborra, S. Inoculation of the leishmania infantum hsp70-ii null mutant induces long-term protection against l. Amazonensis infection in balb/c mice (2021) Microorganisms, 9 (2), art. no. 363, pp. 1-15. Article

106. Soto-Heredero, G., Desdín-Micó, G., Mittelbrunn, M. Mitochondrial dysfunction defines T cell exhaustion (2021) Cell Metabolism, 33 (3), pp. 470-472. Article

107. Suárez, H., Andreu, Z., Mazzeo, C., Toribio, V., Pérez-Rivera, A.E., López-Martín, S., García-Silva, S., Hurtado, B., Morato, E., Peláez, L., Arribas, E.A., Tolentino-Cortez, T., Barreda-Gómez, G., Marina, A.I., Peinado, H., Yáñez-Mó, M. CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells (2021) Journal of Extracellular Vesicles, 10 (7), art. no. e12082, .Article

108. Teran-Navarro, H., Salcines-Cuevas, D., Calderon-Gonzalez, R., Tobes, R., Calvo-Montes, J., Pérez-Del Molino Bernal, I.C., Yañez-Diaz, S., Fresno, M., Alvarez-Dominguez, C. A Comparison Between Recombinant Listeria GAPDH Proteins and GAPDH Encoding mRNA Conjugated to Lipids as Cross-Reactive Vaccines for Listeria, Mycobacterium, and Streptococcus (2021) Frontiers in Immunology, 12, art. no. 632304, .Article

109. Traba, J., Sack, M.N., Waldmann, T.A., Anton, O.M. Immunometabolism at the Nexus of Cancer Therapeutic Efficacy and Resistance (2021) Frontiers in Immunology, 12, art. no. 657293, . Review

110. Villa Gonzalez, M., Pérez-Álvarez, M.J. A 3R-Tau-mediated mechanism in oligodendrocytes: Could it be the key for neuroprotection after stroke? (2021) Neural Regeneration Research, 16 (12), pp. 2401-2402. Review

111. Wessel, J., Petrillo, G., Estevez-Gay, M., Bosch, S., Seeger, M., Dijkman, W.P., Iglesias-Fernández, J., Hidalgo, A., Uson, I., Osuna, S., Schallmey, A. Insights into the molecular determinants of thermal stability in halohydrin dehalogenase HheD2 (2021) FEBS Journal, 288 (15), pp. 4683-4701. Article