Instituto Universitario de Biología Molecular

Rutas de señalización en modelos animales de enfermedades cardiovasculares y metabólicas

Prof. Cristina Murga Montesinos. Catedrática.  Departamento de Biología Molecular. UAM.

Our group has been working for the past decade on analyzing some of the cellular processes and intracellular signal transduction pathways that control and regulate the response of an organism to physiological and pathological processes involving metabolic rewiring. We have focused, in particular, on the integration that occurs among different organs during obesity, insulin resistance and cardiovascular disease conditions.

Using diets to model human disease, our group has studied the response of several metabollicaly-relevant organs and tissues as the heart, adipose tissue or the liver to pathological insults such as nutrient overload. We have also investigated the molecular events controlling the adaptation of the body to physiological responses such as fasting and calorie restriction.

We are paying particular attention to the molecular determinants that are key to how aged animals control these physiopathological responses in comparison to young mice. Specifically, we analyze molecular and cellular events that may differ between aged and young animals in relationship with metabolic responses such as glucose handling, adiposity, vascular function and cardiac or hepatic steatosis among others.

Finally, we have recently initiated a research line aimed at deciphering some of the tissue, cell and molecular aspects that differentiate female and male responses to nutrient overload, insulin resistance, obesity and cardiovascular health.