Instituto Universitario de Biología Molecular

Tetraspanin-enriched membrane microdomains in extracellular vesicles and cell adhesion and migration

Prof. María Yáñez-Mo. Profesora Titular. Departamento de Biología Molecular. UAM.

Our group is focused on the role of tetraspanin-enriched membrane nanodomains in extracellular vesicles (EVs). We pursue both biotechnological applications for EV detection, isolation or characterization as well as fundamental knowledge on tetraspanin involvement in the molecular mechanisms of EV biogenesis, cargo selection and uptake.

Our latest data suggest that tetraspanins finely regulate the dynamics of endosomal compartments and their interrelation with autophagy and mitophagy pathways. Thus, tetraspanins emerge as potent regulators of the metabolic fitness of the cell, with novel therapeutic implications in the fight against cancer.