It is evident that women and men, female and male animals, are biologically different, resulting from genetic, epigenetic, hormonal, and environmental factors. However, the progress in the understanding of the sex-specific physio-pathology is still marginal. Therefore, it is not surprising that such a limited comprehension of the molecular mechanisms hampers the development of appropriate therapeutic strategies.

Our laboratory aims to understand the molecular mechanisms underlying metabolic sex-differences in health and disease, explicitly exploring mitochondria’s role as the central hub where all metabolic functions converge.

We are currently addressing the role of mitochondria leading to a sex-specific response to heart failure and glucose metabolism. Our studies capitalize on in vivo and in vitro analysis combining biochemistry approaches to omics techniques